Chlorpheniramine [Piriton]

Chlorpheniramine as 4mg tablet or 2mg/ml syrup is in class of medicine called antihistamines. It relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery.  It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.

How should Chlorpheniramine be used?

Chlorpheniramine comes as a tablet, a capsule, an extended-release (long-acting) tablet and capsule, a chewable tablet, and a liquid to take by mouth. The regular capsules and tablets, chewable tablets, and liquid are usually taken every 4 to 6 hours as needed. The extended-release (long-acting) tablets and capsules are usually taken twice a day in the morning and evening as needed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take chlorpheniramine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Chlorpheniramine comes alone and in combination with fever and pain reducers, expectorants, cough suppressants, and decongestants. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using 2 or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose.This is especially important if you will be giving cough and cold medications to a child.

Nonprescription cough and cold combination products, including products that contain chlorpheniramine, can cause serious side effects or death in young children. Do not give these products to children younger than 4 years of age. If you give these products to children 4-11 years of age, use caution and follow the package directions carefully.

If you are giving chlorpheniramine or a combination product that contains chlorpheniramine to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give chlorpheniramine products that are made for adults to children.

Before you give a chlorpheniramine product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child’s age on the chart. Ask the child’s doctor if you don’t know how much medication to give the child.

If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.

If you are using the extended-release tablets or capsules, swallow them whole. Do not break, crush, chew, or open them.

Before taking chlorpheniramine,

tell your doctor and pharmacist if you are allergic to chlorpheniramine, any other medications, or any of the ingredients in the chlorpheniramine product you plan to use. Check the package label for a list of the ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: other medications for colds, hay fever, or allergies; medications for anxiety, depression, or seizures; muscle relaxants; narcotic medications for pain; sedatives; sleeping pills; and tranquilizers.

tell your doctor if you have or have ever had asthma, emphysema, chronic bronchitis, or other types of lung disease; glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision); ulcers; diabetes; difficulty urinating (due to an enlarged prostate gland); heart disease; high blood pressure; seizures; or an overactive thyroid gland.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking chlorpheniramine, call your doctor.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking chlorpheniramine.

you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

ask your doctor about the safe use of alcohol while you are taking chlorpheniramine. Alcohol can make the side effects of chlorpheniramine worse.

talk to your doctor about the risks and benefits of taking chlorpheniramine if you are 65 years of age or older. Older adults should not usually take chlorpheniramine because it is not as safe or effective as other medications that can be used to treat the same condition.

What side effects can Chlorpheniramine cause?

Chlorpheniramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness

dry mouth, nose, and throat

nausea

vomiting

loss of appetite

constipation

headache

increased chest congestion

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

vision problems

difficulty urinating

What other information should I know?

Ask your pharmacist any questions you have about chlorpheniramine.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Allergic Rhinitis (Hay Fever)

This type of allergy causes cold-like signs and symptoms, such as a runny nose, itchy eyes, congestion, sneezing and sinus pressure. But unlike a cold, hay fever isn’t caused by a virus. Hay fever is caused by an allergic response to outdoor or indoor allergens, such as pollen, dust mites or pet dander.

Hay fever can make you miserable and affect your performance at work or school and interfere with leisure activities. But you don’t have to put up with annoying symptoms. Learning how to avoid triggers and finding the right treatment can make a big difference.

Symptoms of Hay Fever

Hay fever signs and symptoms usually start immediately after you’re exposed to a specific allergy-causing substance (allergen) and can include:

Runny nose and nasal congestion

Watery or itchy eyes

Sneezing

Cough

Itchy nose, roof of mouth or throat

Sinus pressure and facial pain

Swollen, blue-colored skin under the eyes (allergic shiners)

Decreased sense of smell or taste

Time of year can be a factor

Your hay fever symptoms may start or worsen at a particular time of year, triggered by tree pollen, grasses or weeds, which all bloom at different times. If you’re sensitive to indoor allergens, such as dust mites, cockroaches, mold or pet dander, you may have year-round symptoms. Many people have allergy symptoms all year long, but their symptoms get worse during certain times of the year.

The effects of age
Although hay fever can begin at any age, you’re most likely to develop it during childhood or early adulthood. It’s common for the severity of hay fever reactions to change over the years. For most people, hay fever symptoms tend to diminish slowly, often over decades.

Is it hay fever? Or is it a cold?

Signs and symptoms can be different. Here’s how to tell which one’s causing your symptoms:

Hay fever Signs and symptoms: Runny nose with thin, watery discharge; no fever

Colds: Runny nose with watery or thick yellow discharge; body aches; low-grade fever

Onset of Hay fever is Immediately after exposure to allergens while that of cold is 1-3 days after exposure to a cold virus

Duration for hay fever is as long as you’re exposed to allergens while that of colds is  3-7 days

When to see a doctor

See your doctor if:

You think you may have hay fever

Your symptoms are ongoing and bothersome

Allergy medications aren’t working for you

Allergy medications work, but side effects are a problem

You have another condition that can worsen hay fever symptoms, such as nasal polyps, asthma or frequent sinus infections

Many people — especially children — get used to hay fever symptoms. But getting the right treatment can reduce irritating symptoms. In some cases, treatment may help prevent more-serious allergic conditions, such as asthma or eczema.

You may want to see an allergy specialist (allergist) if:

Your symptoms are severe

Hay fever is a year-round nuisance

Allergy medications aren’t controlling your symptoms

Your allergy medications are causing troublesome side effects

You want to find out whether allergy shots (immunotherapy) might be an option for you

Causes of Hay Fever

During a process called sensitization, your immune system mistakenly identifies a harmless airborne substance as something harmful. Your immune system then starts producing antibodies to this harmless substance. The next time you come in contact with the substance, these antibodies recognize it and signal your immune system to release chemicals, such as histamine, into your bloodstream. These immune system chemicals cause a reaction that leads to the irritating signs and symptoms of hay fever.

Seasonal hay fever triggers include:

Tree pollen, common in the spring, Grass pollen, common in the late spring and summer, Ragweed pollen, common in the fall

Spores from fungi and molds, which can be worse during warm-weather months

Year-round hay fever triggers include:

Dust mites or cockroaches

Dander (dried skin flakes and saliva) from pets, such as cats, dogs or birds

Spores from indoor and outdoor fungi and molds

Hay fever doesn’t mean you’re allergic to hay. Despite its name, hay fever is almost never triggered by hay, and it doesn’t cause a fever.

Risk Factors of Hay Fever

The following factors may increase your risk of developing hay fever:

Having other allergies or asthma
Having a blood relative (such as a parent or sibling) with allergies or asthma
Living or working in an environment that constantly exposes you to allergens — such as animal dander

Complications

Problems that may be associated with hay fever include:

Reduced quality of life. Hay fever can interfere with your enjoyment of activities and cause you to be less productive. For many people, hay fever symptoms lead to absences from work or school.
Poor sleep. Hay fever symptoms can keep you awake or make it hard to stay asleep.
Worsening asthma. If you have asthma, hay fever can worsen signs and symptoms, such as coughing and wheezing.
Sinusitis. Prolonged sinus congestion due to hay fever may increase your susceptibility to sinusitis — an infection or inflammation of the membrane that lines the sinuses.
Ear infection. In children, hay fever often is a factor in middle ear infection (otitis media).

Tests and Diagnosis

Your doctor will ask detailed questions about your personal and family medical history, your signs and symptoms, and your usual way of treating them. Your doctor will also perform a physical examination to look for additional clues about the causes of your signs and symptoms. He or she may also recommend one or both of the following tests:

Skin prick test. During skin testing, small amounts of material that can trigger allergies are pricked into the skin of your arm or upper back and you’re observed for signs of an allergic reaction. If you’re allergic, you develop a raised bump (hive) at the test location on your skin. Allergy specialists usually are best equipped to perform allergy skin tests.
Allergy blood test. A blood test, sometimes called the radioallergosorbent test (RAST), can measure your immune system’s response to a specific allergen. The test measures the amount of allergy-causing antibodies in your bloodstream, known as immunoglobulin E (IgE) antibodies. A blood sample is sent to a medical laboratory, where it can be tested for evidence of sensitivity to possible allergens.

Treatment and Drugs

The best hay fever treatment is to avoid the substances that cause your reaction. However, this isn’t always possible, and you may need additional treatments along with strategies to prevent exposure.

If your hay fever isn’t too severe, over-the-counter medications may be enough to ease your symptoms. For more bothersome symptoms, you may need to take prescription medications. Many people get the best relief from a combination of allergy medications. It may take trying a few before you figure out what works best for you.

If your child has hay fever, talk with your doctor about the best treatment. Some medications are approved for use in children, while others are approved only for adults. If you want to try an over-the-counter medication for your child, be sure to read the labels carefully.

Medications for hay fever include:

Nasal corticosteroids. These prescription nasal sprays help prevent and treat the nasal inflammation, nasal itching and runny nose caused by hay fever. For many people they’re the most effective hay fever medications, and they’re often the first type of medication prescribed. Examples include fluticasone propionate (Flonase), triamcinolone (Nasacort AQ), mometasone (Nasonex) and budesonide (Rhinocort). Nasal corticosteroids are a safe long-term treatment for most people. Side effects can include an unpleasant smell or taste and nose irritation. Steroid side effects are rare.
Antihistamines. These preparations are usually given as pills. However, there are also antihistamine nasal sprays and eyedrops. Antihistamines can help with itching, sneezing and runny nose but have less effect on congestion. They work by blocking histamine, a symptom-causing chemical released by your immune system during an allergic reaction. Older over-the-counter antihistamines such as diphenhydramine (Benadryl) work as well as newer ones, but some types can make you drowsy. Newer oral antihistamines are less likely to make you drowsy. Over-the-counter examples include loratadine (Claritin, Alavert), cetirizine (Zyrtec Allergy) and fexofenadine (Allegra). The prescription antihistamine nasal sprays azelastine (Astelin, Astepro) and olopatadine (Patanase) can relieve nasal symptoms. Antihistamine eyedrops help relieve eye itchiness and eye irritation caused by hay fever.
Decongestants. These medications are available in over-the-counter and prescription liquids, tablets and nasal sprays. Over-the-counter oral decongestants include Sudafed and Drixoral. Nasal sprays include phenylephrine (Neo-Synephrine) and oxymetazoline (Afrin). Oral decongestants can cause a number of side effects, including increased blood pressure, insomnia, irritability and headache. Don’t use a decongestant nasal spray for more than two or three days at a time because it can actually worsen symptoms when used continuously (rebound congestion).
Cromolyn sodium. This medication is available as an over-the-counter nasal spray that must be used several times a day. It’s also available in eyedrop form with a prescription (Crolom). It helps relieve hay fever symptoms by preventing the release of histamine. Cromolyn sodium doesn’t have serious side effects, and it’s most effective when you begin using it before your symptoms start.
Leukotriene modifier. Montelukast (Singulair) is a prescription tablet taken to block the action of leukotrienes — immune system chemicals that cause allergy symptoms such as excess mucus production. It’s especially effective in treating allergy-induced asthma. It’s often used when nasal sprays can’t be tolerated, or when you have mild asthma. It can cause headaches. In rare cases, montelukast has been linked to psychological reactions such as agitation, aggression, hallucinations, depression and suicidal thinking. Seek medical advice right away for any unusual psychological reaction.
Nasal ipratropium. Available in a prescription nasal spray, ipratropium (Atrovent) helps relieve a severe runny nose by preventing the glands in your nose from producing excess fluid. It’s not effective for treating congestion, sneezing or postnasal drip. Mild side effects include nasal dryness, nosebleeds and sore throat. Rarely, it can cause more-severe side effects, such as blurred vision, dizziness and difficult urination. The drug is not recommended for people with glaucoma or men with an enlarged prostate.
Oral corticosteroids. Corticosteroid medications in pill form, such as prednisone, are sometimes used to relieve severe allergy symptoms. Because the long-term use of corticosteroids can cause serious side effects such as cataracts, osteoporosis and muscle weakness, they’re usually prescribed for only short periods of time.

Other treatments for hay fever include:

Allergy shots (immunotherapy). If medications don’t relieve your hay fever symptoms or cause too many side effects, your doctor may recommend allergy shots (immunotherapy or desensitization therapy). Over a period of three to five years, you’ll receive regular injections containing tiny amounts of allergens. The goal is to get your body used to the allergens that cause your symptoms, and decrease your need for medications. Immunotherapy may be especially effective if you’re allergic to cat dander, dust mites, or pollen produced by trees, grass or weeds. In children, immunotherapy may help prevent the development of asthma.
Rinsing your sinuses. Rinsing your nasal passages with distilled, sterile saline (nasal irrigation) is a quick, inexpensive and very effective way to relieve nasal congestion. Rinsing directly flushes out mucus and allergens from your nose. Look for a squeeze bottle or a neti pot — a small container with a spout designed for nose rinsing — at your pharmacy or health food store. Use water that’s distilled, sterile, previously boiled and cooled, or filtered using a filter with an absolute pore size of 1 micron or smaller to make up the saline irrigation solution.

Also be sure to rinse the irrigation device after each use with similarly distilled, sterile, previously boiled and cooled, or filtered water and leave open to air-dry

Atopic Dermatitis (eczema)

Eczema is a condition that makes your skin red and itchy. It’s common in children but can occur at any age. Atopic dermatitis is long lasting (chronic) and tends to flare periodically and then subside. It may be accompanied by asthma or hay fever.

No cure has been found for atopic dermatitis. But treatments and self-care measures can relieve itching and prevent new outbreaks. For example, it helps to avoid harsh soaps and other irritants, apply medicated creams or ointments, and moisturize your skin.

Symptoms Of Dermatitis

Atopic dermatitis (eczema) signs and symptoms vary widely from person to person and include:

Itching, which may be severe, especially at night

Red to brownish-gray patches, especially on the hands, feet, ankles, wrists, neck, upper chest, eyelids, inside the bend of the elbows and knees, and, in infants, the face and scalp

Small, raised bumps, which may leak fluid and crust over when scratched

Thickened, cracked, dry, scaly skin

Raw, sensitive, swollen skin from scratching

Atopic dermatitis most often begins before age 5 and may persist into adolescence and adulthood. For some people, it flares periodically and then clears up for a time, even for several years.

Factors that worsen atopic dermatitis

Most people with atopic dermatitis also have Staphylococcus aureus bacteria on their skin. The staph bacteria multiply rapidly when the skin barrier is broken and fluid is present on the skin. This in turn may worsen symptoms, particularly in young children.

Factors that can worsen atopic dermatitis signs and symptoms include:

Dry skin, which can result from long, hot baths or showers

Scratching, which causes further skin damage

Bacteria and viruses

Stress

Sweat

Changes in heat and humidity

Solvents, cleaners, soaps and detergents

Wool in clothing, blankets and carpets

Dust and pollen

Tobacco smoke and air pollution

Eggs, milk, peanuts, soybeans, fish and wheat, in infants and children

Atopic dermatitis is related to allergies. But eliminating allergens is rarely helpful in clearing the condition. Occasionally, items that trap dust — such as feather pillows, down comforters, mattresses, carpeting and drapes — can worsen the condition.

Causes of Dermatitis

The exact cause of atopic dermatitis (eczema) is unknown. Healthy skin helps retain moisture and protects you from bacteria, irritants and allergens. Eczema is likely related to a mix of factors:

Dry, irritable skin, which reduces the skin’s ability to be an effective barrier

A gene variation that affects the skin’s barrier function

Immune system dysfunction

Bacteria, such as Staphylococcus aureus, on the skin that creates a film that blocks sweat glands

Environmental conditions

Treatment and Drugs

Atopic dermatitis can be persistent. You may need to try various treatments over months or years to control it. And even if you respond to treatment, your signs and symptoms may return (flare).

It’s important to recognize the condition early so you can start treatment. If regular moisturizing and other self-care steps don’t help, your doctor may suggest the following treatments and drugs:

Medications

Creams that control itching and inflammation. Your doctor may prescribe a corticosteroid cream or ointment. Talk with your doctor before using any topical corticosteroid. Overuse of this drug may cause skin irritation or discoloration, thinning of the skin, infections, and stretch marks.

Creams that help repair the skin. Drugs called calcineurin inhibitors — such as tacrolimus (Protopic) and pimecrolimus (Elidel) — affect your immune system. Applied to the skin, they help maintain normal skin, control itching and reduce flares of atopic dermatitis. Due to possible side effects, these prescription-only drugs are used only when other treatments have failed or if someone can’t tolerate other treatments. They are approved for children older than 2 and for adults.

Drugs to fight infection. You may need antibiotics if you have a bacterial skin infection or an open sore or cracked skin caused by scratching. Your doctor may recommend taking oral antibiotics for a short time to treat an infection. Or he or she may suggest you take it for a longer time to reduce bacteria on your skin and to prevent another infection.

Oral anti-itch drugs. If itching is severe, oral antihistamines may help. Diphenhydramine (Benadryl, others) can make you sleepy and may be especially helpful at bedtime.

Oral or injected drugs that control inflammation. For more-severe cases, your doctor may prescribe oral corticosteroids — such as prednisone — or an injected corticosteroid. These drugs are effective but can’t be used long term because of potential serious side effects. Continue moisturizing and using other self-care remedies to prevent a flare-up after you stop taking the corticosteroids.